Relationship between viral load and clinical stages in human immunodeficiency virus-1 and tuberculosis co-infected patients at Jaramogi Oginga Odinga Teaching and Referral Hospital and Kisumu County Hospital, Kenya.
3. Kambale, K. J., Guyah, B., et Ouma, C. (2025).
Lien vers l'Article
Membre de la CRISIA Asbl : Kambale Kisuba Jacques
Introduction: In dual tuberculosis and human immunodeficiency virus infection, each disease speeds up the progression of the other. The risk of death in TB-HIV co-infected individuals is also twice that of HIV infected individuals without TB. It is important to get a viral load test to determine the level of HIV in blood for treatment assessment. This study aimed to determine the HIV viral load levels in various clinical stages of HIV infection and clinical form of tuberculosis (pulmonary and extra-pulmonary TB). Methodology: This research adopted a cross sectional design involving data collection from a population of patients aged 5 to 65 years’ old; tested HIV positive and co-infected with MTB. For sampling, we considered 88 – 44 from Jaramogi Oginga Odinga Teaching and Referral Hospital (JOOTRH) and 44 others from Kisumu County Hospital (KCH). Adult participants were consented and children gave their assent despite consent from their parents. Whole blood was drawn from the 88 clients for viral load testing. Pearson Chi-square Test and Fisher’s Exact Tests were used through SPSS 20.0 for data analysis. Results: Findings showed that most of the study participants (78.0%) with high viral load (> 10.000 copies/ml) were found in HIV stage three with pulmonary TB while 22.0% were in HIV stage four with extra-pulmonary TB. There was a statistical significance between viral load and HIV clinical stages (p = 0.004) and also a statistical significance between viral load and TB clinical form (p= 0.006). Conclusion: Overall, the results showed a positive relationship between viral load and HIV clinical stages, and also with pulmonary TB; but not with extra-pulmonary TB. These findings are useful to enhance HIV and TB co-infection management system by enabling viral load testing repeats to follow up HIV a
0 Commentaire(s)